1.8M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| W. Michael Flanagan | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2025 | 20,000 | 116,500 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.13 per share. | 11 Mar 2025 | 20,000 | 91,975 | - | 30.1 | 602,614 | Common Stock |
| W. Michael Flanagan | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.22 per share. | 11 Mar 2025 | 20,000 | 111,975 | - | 14.2 | 284,400 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 5,875 | 19,375 | - | - | Stock Option (Right to Buy) | |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 29.41 per share. | 03 Mar 2025 | 5,875 | 50,554 | - | 29.4 | 172,807 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.70 per share. | 03 Mar 2025 | 5,875 | 56,429 | - | 14.7 | 86,363 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.65 per share. | 03 Feb 2025 | 5,875 | 56,429 | - | 16.7 | 97,819 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 5,875 | 34,675 | - | - | Stock Option (Right to Buy) | |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 32.16 per share. | 03 Feb 2025 | 5,875 | 50,554 | - | 32.2 | 188,918 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 28.60 per share. | 21 Jan 2025 | 1,872 | 12,958 | - | 28.6 | 53,537 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,622 | 106,320 | - | 28.6 | 46,378 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,665 | 104,655 | - | 28.6 | 47,608 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 4,738 | 343,070 | - | 28.6 | 135,475 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 5,659 | 337,411 | - | 28.6 | 161,817 | Common Stock |
| W. Michael Flanagan | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.60 per share. | 21 Jan 2025 | 3,860 | 93,787 | - | 28.6 | 110,383 | Common Stock |
| W. Michael Flanagan | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,812 | 91,975 | - | 28.6 | 51,809 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 28.60 per share. | 21 Jan 2025 | 1,221 | 104,908 | - | 28.6 | 34,917 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,738 | 106,129 | - | 28.6 | 49,695 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 28.60 per share. | 21 Jan 2025 | 670 | 58,000 | - | 28.6 | 19,159 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 30.16 per share. | 21 Jan 2025 | 5,629 | 50,554 | - | 30.2 | 169,776 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,817 | 56,183 | - | 28.6 | 51,953 | Common Stock |
| Kathleen P. Gallagher | Chief Program Officer | Sale of securities on an exchange or to another person at price $ 28.59 per share. | 21 Jan 2025 | 1,295 | 58,670 | - | 28.6 | 37,024 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 25,000 | 107,942 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 82,500 | 347,808 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 165,000 | 165,000 | - | - | Stock Option (Right to Buy) | |
| Eric Mosbrooker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Eric Mosbrooker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 25,000 | 61,120 | - | 0 | Common Stock | |
| W. Michael Flanagan | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 25,000 | 97,647 | - | 0 | Common Stock | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 25,000 | 107,867 | - | 0 | Common Stock | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kathleen P. Gallagher | Chief Program Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 25,000 | 59,965 | - | 0 | Common Stock | |
| Kathleen P. Gallagher | Chief Program Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Charles Calderaro | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Charles Calderaro | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2025 | 40,000 | 40,000 | - | 0 | Common Stock | |
| Flanagan Michael W. | CSTO | Sale of securities on an exchange or to another person at price $ 32.66 per share. | 18 Dec 2024 | 12,742 | 72,647 | - | 32.7 | 416,154 | Common Stock |
| Michael Maclean F. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 32.66 per share. | 18 Dec 2024 | 11,151 | 82,942 | - | 32.7 | 364,192 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.66 per share. | 18 Dec 2024 | 31,855 | 265,308 | - | 32.7 | 1,040,384 | Common Stock |
| McCarthy Teresa | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 32.66 per share. | 18 Dec 2024 | 11,151 | 82,867 | - | 32.7 | 364,192 | Common Stock |
| McCarthy Teresa | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 33.26 per share. | 16 Dec 2024 | 25,000 | 94,018 | - | 33.3 | 831,605 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 25,000 | 57,500 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.22 per share. | 16 Dec 2024 | 25,000 | 119,018 | - | 14.2 | 355,500 | Common Stock |
| Flanagan Michael W. | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2024 | 24,000 | 86,000 | - | - | Stock Option (Right to Buy) | |
| W. Flanagan Michael | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.47 per share. | 11 Dec 2024 | 24,000 | 109,389 | - | 22.5 | 539,280 | Common Stock |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 35.77 per share. | 11 Dec 2024 | 24,000 | 85,389 | - | 35.8 | 858,401 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2024 | 3,323 | 0 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 42.12 per share. | 19 Nov 2024 | 3,323 | 14,830 | - | 42.1 | 139,973 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Nov 2024 | 3,323 | 18,153 | - | 1.2 | 4,121 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.22 per share. | 18 Nov 2024 | 25,000 | 119,018 | - | 14.2 | 355,500 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2024 | 25,000 | 82,500 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 41.14 per share. | 18 Nov 2024 | 25,000 | 94,018 | - | 41.1 | 1,028,520 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 46.22 per share. | 06 Nov 2024 | 27,262 | 94,093 | - | 46.2 | 1,260,017 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.33 per share. | 06 Nov 2024 | 13,875 | 94,093 | - | 45.3 | 629,008 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2024 | 65,182 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2024 | 13,875 | 60,125 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.57 per share. | 06 Nov 2024 | 13,875 | 107,968 | - | 6.6 | 91,159 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.33 per share. | 06 Nov 2024 | 65,182 | 94,093 | - | 45.3 | 2,954,954 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.82 per share. | 06 Nov 2024 | 65,182 | 159,275 | - | 8.8 | 574,905 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 46.63 per share. | 21 Oct 2024 | 5,000 | 14,830 | - | 46.6 | 233,168 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2024 | 5,000 | 3,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 21 Oct 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 48.52 per share. | 16 Oct 2024 | 25,000 | 94,018 | - | 48.5 | 1,213,010 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2024 | 25,000 | 107,500 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.22 per share. | 16 Oct 2024 | 25,000 | 119,018 | - | 14.2 | 355,500 | Common Stock |
| Tamar Thompson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2024 | 30,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Tamar Thompson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.63 per share. | 07 Oct 2024 | 30,000 | 30,000 | - | 27.6 | 828,900 | Common Stock |
| Tamar Thompson | Director | Sale of securities on an exchange or to another person at price $ 44.98 per share. | 07 Oct 2024 | 30,000 | 0 | - | 45.0 | 1,349,259 | Common Stock |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.75 per share. | 01 Oct 2024 | 62,500 | 147,889 | - | 26.8 | 1,671,875 | Common Stock |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 62,500 | 25,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 47.62 per share. | 01 Oct 2024 | 62,500 | 85,389 | - | 47.6 | 2,976,113 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 45.73 per share. | 19 Sep 2024 | 5,000 | 14,830 | - | 45.7 | 228,658 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Sep 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Sep 2024 | 5,000 | 8,323 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 121,355 | - | 0 | Common Stock | |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 19 Sep 2024 | 11,510 | 96,355 | - | 44 | 506,440 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 107,865 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 62,500 | 267,543 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 62,500 | 297,163 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 19 Sep 2024 | 32,880 | 234,663 | - | 44.0 | 1,446,723 | Common Stock |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 43.89 per share. | 19 Sep 2024 | 11,847 | 85,389 | - | 43.9 | 519,996 | Common Stock |
| W. Michael Flanagan | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 97,718 | - | 0 | Common Stock | |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 19 Sep 2024 | 13,153 | 72,718 | - | 44.0 | 578,737 | Common Stock |
| W. Michael Flanagan | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 85,871 | - | 0 | Common Stock | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 94,018 | - | 0 | Common Stock | |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 19 Sep 2024 | 13,153 | 69,018 | - | 44.0 | 578,737 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2024 | 25,000 | 82,171 | - | 0 | Common Stock | |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.75 per share. | 11 Sep 2024 | 62,500 | 138,265 | - | 26.8 | 1,671,875 | Common Stock |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2024 | 34,000 | 110,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2024 | 62,500 | 87,500 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 11 Sep 2024 | 14,894 | 60,871 | - | 40.4 | 601,676 | Common Stock |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 11 Sep 2024 | 34,000 | 75,765 | - | 40.4 | 1,373,556 | Common Stock |
| W. Michael Flanagan | CSTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.47 per share. | 11 Sep 2024 | 34,000 | 109,765 | - | 22.5 | 763,980 | Common Stock |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 11 Sep 2024 | 62,500 | 75,765 | - | 40.4 | 2,525,013 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 11 Sep 2024 | 25,000 | 57,171 | - | 40.4 | 1,010,043 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2024 | 25,000 | 132,500 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.22 per share. | 11 Sep 2024 | 25,000 | 82,171 | - | 14.2 | 355,500 | Common Stock |
| Arthur A. Levin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Sep 2024 | 22,500 | 131,372 | - | 0 | Common Stock | |
| Arthur A. Levin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Sep 2024 | 22,500 | 22,500 | - | 0 | Common Stock | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 45.19 per share. | 19 Aug 2024 | 5,000 | 14,830 | - | 45.2 | 225,947 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2024 | 5,000 | 13,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Aug 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 06 Aug 2024 | 28,000 | 233,043 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 43.35 per share. | 06 Aug 2024 | 28,000 | 205,043 | - | 43.4 | 1,213,822 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 28,000 | 461,015 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 19 Jul 2024 | 5,000 | 14,830 | - | 45.0 | 225,069 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jul 2024 | 5,000 | 18,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Jul 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 09 Jul 2024 | 28,000 | 233,043 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2024 | 28,000 | 489,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 39.93 per share. | 09 Jul 2024 | 28,000 | 205,043 | - | 39.9 | 1,118,082 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 37.59 per share. | 20 Jun 2024 | 5,000 | 14,830 | - | 37.6 | 187,951 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2024 | 5,000 | 23,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 20 Jun 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.13 per share. | 17 Jun 2024 | 11,228 | 57,865 | - | 39.1 | 439,345 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 69,093 | - | 0 | Common Stock | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 82,865 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 39.13 per share. | 17 Jun 2024 | 32,074 | 142,543 | - | 39.1 | 1,255,040 | Common Stock |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 62,500 | 205,043 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 62,500 | 174,617 | - | 0 | Common Stock | |
| W. Michael Flanagan | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 75,765 | - | 0 | Common Stock | |
| W. Michael Flanagan | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 60,871 | - | 0 | Common Stock | |
| W. Michael Flanagan | CSTO | Sale of securities on an exchange or to another person at price $ 39.13 per share. | 17 Jun 2024 | 10,106 | 50,765 | - | 39.1 | 395,445 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 57,171 | - | 0 | Common Stock | |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 39.13 per share. | 17 Jun 2024 | 9,864 | 32,171 | - | 39.1 | 385,972 | Common Stock |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 25,000 | 42,035 | - | 0 | Common Stock | |
| Carsten Boess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Troy E. Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Noreen Roth Henig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Tamar Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,490 | - | - | Stock Option (Right to Buy) | |
| Jean Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 13,489 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 40.08 per share. | 12 Jun 2024 | 60,000 | 153,872 | - | 40.1 | 2,404,782 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 35.07 per share. | 12 Jun 2024 | 40,000 | 213,872 | - | 35.1 | 1,402,628 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.82 per share. | 12 Jun 2024 | 104,245 | 148,338 | - | 8.8 | 919,441 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 35.72 per share. | 12 Jun 2024 | 104,245 | 44,093 | - | 35.7 | 3,723,141 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 104,245 | 65,182 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 100,000 | 717,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 40.08 per share. | 12 Jun 2024 | 35,767 | 112,117 | - | 40.1 | 1,433,484 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Jun 2024 | 35,767 | 147,884 | - | 1.2 | 44,351 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 40.08 per share. | 12 Jun 2024 | 164,233 | 112,117 | - | 40.1 | 6,581,802 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Jun 2024 | 164,233 | 276,350 | - | 1.2 | 203,649 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.73 per share. | 12 Jun 2024 | 100,000 | 112,117 | - | 35.7 | 3,573,020 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Jun 2024 | 100,000 | 212,117 | - | 1.2 | 124,000 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 35,767 | 517,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 164,233 | 552,782 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 04 Jun 2024 | 28,000 | 140,117 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jun 2024 | 28,000 | 817,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 27.42 per share. | 04 Jun 2024 | 28,000 | 112,117 | - | 27.4 | 767,780 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2024 | 5,000 | 28,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 20 May 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 29.90 per share. | 20 May 2024 | 5,000 | 14,830 | - | 29.9 | 149,481 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.82 per share. | 14 May 2024 | 75,000 | 119,093 | - | 8.8 | 661,500 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.28 per share. | 14 May 2024 | 75,000 | 44,093 | - | 28.3 | 2,121,045 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 75,000 | 169,427 | - | - | Stock Option (Right to Buy) | |
| Simona Skerjanec | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 42,308 | 42,308 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 07 May 2024 | 28,000 | 140,117 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2024 | 28,000 | 845,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.54 per share. | 07 May 2024 | 28,000 | 112,117 | - | 25.5 | 715,050 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2024 | 5,000 | 33,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Apr 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 22.82 per share. | 19 Apr 2024 | 5,000 | 14,830 | - | 22.8 | 114,123 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 27.11 per share. | 03 Apr 2024 | 20,000 | 253,872 | - | 27.1 | 542,214 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 02 Apr 2024 | 28,000 | 140,117 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2024 | 28,000 | 873,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 26.25 per share. | 02 Apr 2024 | 28,000 | 112,117 | - | 26.2 | 734,919 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 23.97 per share. | 19 Mar 2024 | 5,000 | 14,830 | - | 24.0 | 119,848 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2024 | 5,000 | 38,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 19 Mar 2024 | 5,000 | 19,830 | - | 1.2 | 6,200 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2024 | 40,000 | 244,427 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.52 per share. | 13 Mar 2024 | 40,000 | 44,093 | - | 24.5 | 980,760 | Common Stock |
| Michael F. Maclean | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.82 per share. | 13 Mar 2024 | 40,000 | 84,093 | - | 8.8 | 352,800 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Mar 2024 | 25,000 | 43,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 12 Mar 2024 | 2,641 | 14,830 | - | 22 | 58,102 | Common Stock |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 22.04 per share. | 12 Mar 2024 | 25,000 | 17,471 | - | 22.0 | 550,915 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Mar 2024 | 25,000 | 42,471 | - | 1.2 | 31,000 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 08 Mar 2024 | 84,000 | 196,117 | - | 1.2 | 104,160 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 21.39 per share. | 08 Mar 2024 | 84,000 | 112,117 | - | 21.4 | 1,796,710 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 28,000 | 901,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 84,000 | 929,015 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.63 per share. | 08 Mar 2024 | 28,000 | 112,117 | - | 22.6 | 633,682 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 08 Mar 2024 | 28,000 | 140,117 | - | 1.2 | 34,720 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 01 Mar 2024 | 84,000 | 196,117 | - | 1.2 | 104,160 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.13 per share. | 01 Mar 2024 | 84,000 | 112,117 | - | 20.1 | 1,691,306 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 84,000 | 1,013,015 | - | - | Stock Option (Right to Buy) | |
| Levin A. Arthur | Director | Sale of securities on an exchange or to another person at price $ 10.13 per share. | 22 Jan 2024 | 1,859 | 17,471 | - | 10.1 | 18,832 | Common Stock |
| W. Flanagan Michael | CSTO | Sale of securities on an exchange or to another person at price $ 10.13 per share. | 20 Jan 2024 | 4,129 | 35,871 | - | 10.1 | 41,827 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 10.13 per share. | 20 Jan 2024 | 5,092 | 44,008 | - | 10.1 | 51,582 | Common Stock |
| Maclean F. Michael | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.13 per share. | 20 Jan 2024 | 1,616 | 16,884 | - | 10.1 | 16,370 | Common Stock |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 10.13 per share. | 20 Jan 2024 | 2,065 | 17,035 | - | 10.1 | 20,918 | Common Stock |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 62,500 | 67,209 | - | 0 | Common Stock | |
| McCarthy Teresa | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 78,000 | 78,000 | - | - | Stock Option (Right to Buy) | |
| F. Michael Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 106,000 | 106,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 22,500 | 27,209 | - | 0 | Common Stock | |
| Flanagan Michael W. | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 20,000 | 20,290 | - | 0 | Common Stock | |
| Michael Flanagan W. | CSTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 88,000 | 88,000 | - | - | Stock Option (Right to Buy) | |
| McCarthy Teresa | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2024 | 16,500 | 17,458 | - | 0 | Common Stock | |
| Troy Wilson E. | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2023 | 250,000 | 13,711 | - | 0 | Common Stock | |
| Wilson Troy E. | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2023 | 300,000 | 263,711 | - | 0 | Common Stock | |
| Troy Wilson E. | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2023 | 250,000 | 300,000 | - | 0 | Common Stock | |
| Troy E. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 12 Dec 2023 | 300,000 | 300,000 | - | 0 | Common Stock | |
| Carsten Boess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Troy E. Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Noreen Roth Henig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Eric Mosbrooker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Tamar Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Jean Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2023 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Sale of securities on an exchange or to another person at price $ 22.01 per share. | 15 Mar 2023 | 100 | 19,330 | - | 22.0 | 2,201 | Common Stock |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 100 | 68,323 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 15 Mar 2023 | 100 | 19,430 | - | 1.2 | 124 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 14 Feb 2023 | 10,000 | 29,330 | - | 1.2 | 12,400 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 10,000 | 68,423 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 24.24 per share. | 14 Feb 2023 | 523 | 19,330 | - | 24.2 | 12,677 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.62 per share. | 14 Feb 2023 | 9,477 | 19,853 | - | 23.6 | 223,890 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.26 per share. | 01 Feb 2023 | 3,221 | 53,352 | - | 24.3 | 78,141 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 01 Feb 2023 | 900 | 54,252 | - | 1.2 | 1,116 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.27 per share. | 01 Feb 2023 | 900 | 53,352 | - | 24.3 | 21,844 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 01 Feb 2023 | 45,879 | 99,231 | - | 1.2 | 56,890 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 24.36 per share. | 01 Feb 2023 | 45,879 | 53,352 | - | 24.4 | 1,117,741 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 01 Feb 2023 | 3,221 | 56,573 | - | 1.2 | 3,994 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 900 | 1,146,115 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 45,879 | 1,100,236 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 3,221 | 1,097,015 | - | - | Stock Option (Right to | |
| Arthur A. Levin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 144,000 | 144,000 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 18,000 | 19,330 | - | 0 | Common Stock | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 148,000 | 148,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 18,500 | 21,852 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 50,000 | 53,352 | - | 0 | Common Stock | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 400,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 40,000 | 40,290 | - | 0 | Common Stock | |
| W. Michael Flanagan | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 144,000 | 144,000 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 108,000 | 108,000 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2023 | 20,000 | 20,958 | - | 0 | Common Stock | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 12 Jan 2023 | 10,000 | 1,330 | - | 22.0 | 220,028 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2023 | 10,000 | 78,423 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Jan 2023 | 10,000 | 11,330 | - | 1.2 | 12,400 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2022 | 40,000 | 88,423 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.01 per share. | 29 Dec 2022 | 40,000 | 1,330 | - | 22.0 | 880,568 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 29 Dec 2022 | 40,000 | 41,330 | - | 1.2 | 49,600 | Common Stock |
| Sarah Boyce | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.47 per share. | 15 Aug 2022 | 100 | 0 | - | 22.5 | 2,247 | Common Stock |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2022 | 100 | 1,196,915 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 15 Aug 2022 | 100 | 100 | - | 1.2 | 124 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Aug 2022 | 34,758 | 63,828 | - | 1.2 | 43,100 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2022 | 14,003 | 27,740 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2022 | 27,740 | 0 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2022 | 34,758 | 131,922 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2022 | 3,499 | 128,423 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 12 Aug 2022 | 14,003 | 15,333 | - | 0.5 | 7,422 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 12 Aug 2022 | 14,003 | 1,330 | - | 22 | 308,066 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 12 Aug 2022 | 27,740 | 29,070 | - | 0.5 | 14,702 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.12 per share. | 12 Aug 2022 | 62,498 | 1,330 | - | 22.1 | 1,382,343 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 12 Aug 2022 | 3,499 | 4,829 | - | 1.2 | 4,339 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.08 per share. | 12 Aug 2022 | 3,499 | 1,330 | - | 22.1 | 77,257 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 115,500 | 115,500 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 131,250 | 131,250 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 136,500 | 136,500 | - | - | Stock Option (Right to Buy) | |
| Teresa McCarthy | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 157,500 | 157,500 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 18 Nov 2021 | 604 | 26,330 | - | 0.5 | 320 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 18 Nov 2021 | 24,396 | 25,726 | - | 1.2 | 30,251 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2021 | 604 | 41,743 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2021 | 24,396 | 166,770 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.89 per share. | 18 Nov 2021 | 25,000 | 1,330 | - | 27.9 | 697,218 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.97 per share. | 24 Jun 2021 | 17,453 | 3,977 | - | 28.0 | 488,166 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 24 Jun 2021 | 3,083 | 21,430 | - | 0.5 | 1,634 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 24 Jun 2021 | 17,017 | 18,347 | - | 1.2 | 21,101 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 24 Jun 2021 | 100 | 1,430 | - | 1.2 | 124 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.76 per share. | 24 Jun 2021 | 100 | 1,330 | - | 27.8 | 2,776 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 3,083 | 42,347 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 17,017 | 191,166 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 100 | 208,183 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.14 per share. | 24 Jun 2021 | 2,647 | 1,330 | - | 29.1 | 77,133 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 17 Jun 2021 | 200 | 1,530 | - | 1.2 | 248 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2021 | 200 | 208,283 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.75 per share. | 17 Jun 2021 | 200 | 1,330 | - | 27.8 | 5,550 | Common Stock |
| Carsten Boess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Roderick Wong | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Edward M. Kaye | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Troy E. Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Noreen Henig | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.02 per share. | 14 Jun 2021 | 23,019 | 0 | - | 26.0 | 599,067 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 25.92 per share. | 14 Jun 2021 | 14,003 | 23,019 | - | 25.9 | 362,921 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.24 per share. | 16 Mar 2021 | 2,625 | 2,625 | - | 1.2 | 3,255 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2021 | 1,975 | 45,430 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2021 | 2,625 | 208,483 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.87 per share. | 16 Mar 2021 | 4,600 | 0 | - | 27.9 | 128,181 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 16 Mar 2021 | 1,975 | 4,600 | - | 0.5 | 1,047 | Common Stock |
| Arthur A. Levin | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Mar 2021 | 37,022 | 37,022 | - | 0 | Common Stock | |
| Arthur A. Levin | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 16 Mar 2021 | 37,022 | 273,872 | - | 0 | Common Stock | |
| Arthur A. Levin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 120,000 | 120,000 | - | - | Stock Option (Right to Buy) | |
| Michael F. Maclean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 92,000 | 92,000 | - | - | Stock Option (Right to Buy) | |
| Sarah Boyce | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Joseph Baroldi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 87,000 | 87,000 | - | - | Stock Option (Right to Buy) | |
| Jae B. Kim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2021 | 82,000 | 82,000 | - | - | Stock Option (Right to Buy) | |
| W. Michael Flanagan | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2021 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Tamar Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Jean Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2021 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Troy E. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 22 Dec 2020 | 100,000 | 100,000 | - | 0 | Common Stock | |
| Troy E. Wilson | Director | Other type of transaction at price $ 0.00 per share. | 22 Dec 2020 | 100,000 | 89,618 | - | 0 | Common Stock | |
| Jae B. Kim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jul 2020 | 375,266 | 375,266 | - | - | Stock Option (Right to Buy) | |
| Arthur A. Levin | Chief Scientific Officer | 16 Jun 2020 | 16,751 | 310,894 | - | - | Common Stock | ||
| Arthur A. Levin | Chief Scientific Officer | 16 Jun 2020 | 35,337 | 0 | - | - | Series A Preferred Stock | ||
| Troy E. Wilson | Director | 16 Jun 2020 | 35,374 | 0 | - | - | Series B Preferred Stock | ||
| Troy E. Wilson | Director | 16 Jun 2020 | 108,504 | 0 | - | - | Series C Preferred Stock | ||
| Troy E. Wilson | Director | 16 Jun 2020 | 189,042 | 805,301 | - | - | Common Stock | ||
| Troy E. Wilson | Director | 16 Jun 2020 | 254,907 | 0 | - | - | Series A Preferred Stock |